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Molecular Surveillance in Gastrointestinal Cancers: Advances in Circulating Tumor DNA Analysis

FACULTY


Mariana Byndloss, DVM, PhD
Assistant Professor
Vanderbilt University School of Medicine
 
Andrea Cercek, MD
Associate Attending
Memorial Sloan Kettering Cancer Center
 
Kristen K. Ciombor, MD, MSCI
Assistant Professor of Medicine
Vanderbilt-Ingram Cancer Center
 
Howard S. Hochster, MD
Distinguished Professor of Medicine, Associate Cancer Center Director
Rutgers Cancer Institute of New Jersey

David H. Ilson, MD, PhD
Weill Cornell Medical College, Memorial Hospital
Memorial Sloan Kettering Cancer Center
New York, New York
 
Aparna Kalyan, MD, MBBS
Associate Professor of Medicine (Hematology and Oncology)
Northwestern Medicine, Feinberg School of Medicine
 
Christopher Lieu, MD
Associate Professor, Medicine
University of Colorado
 
Van Morris, MD
Assistant Professor
MD Anderson Cancer Center
 
Michael J. Overman, MD
Professor, Gastrointestinal Medical Oncology
MD Anderson Cancer Center, The University of Texas
 
Aparna Parikh, MD, MPH
Assistant Professor, Medicine; Medical Director, Center for Young Adult Colorectal Cancer
Harvard Medical School; Massachusetts General Hospital
 
Kanwal PS Raghav, MD, MBBS
Associate Professor, Gastrointestinal Medical Oncology; Medical Director, Division of Ambulatory Treatment Centers
The University of Texas MD Anderson Cancer Center
 
Neil H. Segal, MD, PhD
Associate Attending
Memorial Sloan Kettering Cancer Center
 
Zsofia K. Stadler, MD
Associate Attending Physician
Memorial Sloan Kettering Cancer Center
 
Josep Tabernero, MD
Head, Medical Oncology Department
Vall d’Hebron University Hospital

PROVIDER STATEMENT

Provided by North American Center for Continuing Medical Education, LLC (NACCME), an HMP Company.

For questions regarding this educational activity, please call 609-371-1137 or email info@naccme.com.

INTENDED LEARNERS

This educational activity is designed to meet the educational needs of those who are involved and/or interested in the treatment of patients with GI cancers, community oncologists, physicians, physician assistants, physicians-in-training, oncology nurses, and pharmacists.

OVERVIEW

The development of personalized, genome-driven management of GI cancers has long been a subject of oncology research. Recent technical advances have enabled the comprehensive genomic profiling of ctDNA, allowing high specificity and collection of robust and reproducible data through a noninvasive procedure (blood sample). Clinical applications include diagnostic genomic profiling, monitoring of radicality in surgical outcomes, evaluating response or resistance to systemic treatments, and quantifying minimal residual disease. NGS-based approaches are able to detect a larger number of variants than polymerase chain reaction (PCR)-based strategies and are able to track the evolutionary dynamics and heterogeneity of tumors, while detecting very early emergence of therapy resistance, residual disease and recurrence.

This webcast focuses on the advances in ctDNA analysis in GI cancers.

LEARNING OBJECTIVES

After participating in this activity, learners should be better able to:

  • Summarize the role of NGS-based ctDNA analyses in the molecular surveillance of GI malignancies
  • Evaluate strengths and limitations of available assays for NGS-based ctDNA testing
  • Incorporate ctDNA analyses into management approaches regarding the monitoring of treatment response and disease recurrence

CLAIMING CREDIT

To be eligible for credit, participants must complete the online activity and the evaluation. Upon completing the activity, there will be instructions on how to complete the evaluation and print a certificate or other documentation of credit.

Release Date: November 29, 2021 
Expiration Date: November 29, 2022 
Estimated Time to Complete: 160 minutes

There is no fee associated with this activity.

COMMERCIAL SUPPORT

Supported by educational grants from: Natera, Inc.

CONTINUING EDUCATION

 

In support of improving patient care, this activity has been planned and implemented by North American Center for Continuing Medical Education (NACCME) and Imedex. NACCME is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

PHYSICIANS

NACCME designates this internet enduring activity for a maximum of 2.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

NURSE PRACTITIONERS

American Academy of Nurse Practitioners National Certification Program accepts AMA PRA Category 1 Credit™ from organizations accredited by the ACCME.

NURSING

This continuing nursing education internet enduring activity awards 2.0 contact hours.

Provider approved by the California Board of Registered Nursing, Provider #13255 for 2.0 contact hours. 

PHARMACY

This internet enduring, knowledge-based activity (Universal Activity Number: JA0006201-0000-21-208-H01-P) has been approved for a maximum of 2.0 contact hours (0.2 CEUs).

The certificate is not the official record of your participation in the activity. The official record of credit will be the information in the CPE Monitor system. Following ACPE Policy, NACCME must transmit your claim to CPE Monitor within 60 days from the date you complete this CPE activity. NACCME is not able to report your claimed credit after this 60-day period. Eligibility for pharmacy credit is contingent upon the successful completion of a post-test and/or evaluation for each activity or session attended.

PHYSICIAN ASSISTANTS

NACCME has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with the AAPA CME Criteria. This internet enduring activity is designated for 2.0 AAPA Category 1 credits. PAs should only claim credit commensurate with the extent of their participation.

USE OF PROPRIETARY NAMES

This continuing medical education activity may include device or medicine brand names for participant clarity purposes only, due to the presence of different branded versions of the same product. No product promotion or recommendation should be inferred.

UNAPPROVED AND/OR INVESTIGATIONAL USES OF DRUGS AND DEVICES

This activity may contain information about experimental and other uses of drugs or devices that are not currently approved by the European Medicines Agency (EMA) of the European Union or the Food and Drug Administration (FDA) of the United States. Participants are strongly encouraged to consult approved product labeling for any drug or device mentioned in this activity before use. The opinions expressed during this activity are the opinions of the respective authors, presenters or moderators and do not necessarily reflect the opinions of NACCME.

DISCLAIMERS

The material presented and related discussions are not intended to be medical advice, and the presentation or discussion of such material is not intended to create and does not establish a physician-patient relationship. Medical advice of any nature should be sought from an individual’s own physician.

Neither NACCME nor any of its subsidiaries or affiliates is affiliated with, or formally endorsed by a medical society.

The opinions expressed in this educational activity are those of the faculty and are not attributable to NACCME or HMP. Clinical judgment must guide each professional in weighing the benefits of treatment against the risk of toxicity. Dosages, indications, and methods of use for products referred to in this activity are not necessarily the same as indicated in the package insert for each product, may reflect the clinical experience of the presenters, and may be derived from the professional literature or other clinical sources. Consult complete prescribing information before administering.

DISCLOSURE OF RELEVANT FINANCIAL RELATIONSHIPS

NACCME, LLC is an independent provider(s) of continuing medical education. NACCME, LLC has no proprietary or financial interest in medical or healthcare products over which the FDA (USA) or EMA (EU) has regulatory authority.

NACCME, LLC assures that all educational materials are reviewed to ensure for the absence of commercial bias, fair balance, scientific objectivity, and levels of evidence. The educational activity will not be influenced by commercial organizations and will not conflict with any other scheduled educational activities.

According to the disclosure policy of NACCME, faculty, editors, managers, and other individuals who are in a position to control content are required to disclose any relevant financial relationships with relevant commercial companies related to this activity. All relevant conflicts of interest that are identified are reviewed for potential conflicts of interest. If a conflict is identified, it is the responsibility of NACCME to initiate a mechanism to resolve the conflict. The existence of these interests or relationships is not viewed as implying bias or decreasing the value of the presentation.

Faculty

The faculty has reported the following:

Andrea Cercek: Advisory Board-Array Biopharma, Bayer; Grant/Research Support-GSK (GlaxoSmithKline Group), Rgenix, Seattle Genetics

Kristen K. Ciombor: Grant/Research Support-Array Biopharma, BMS, Calithera, Daiichi Sankyo, Incyte, Merck, Nucana, Pfizer; Consultant-Lilly, Merck; Advisory Board-Merck, Pfizer
 
Howard S. Hochster: Advisory Board-Bayer, Genentech, Merck; Consultant-Bayer, Genentech, Merck; Speaker's Bureau- Natera
 
David H. Ilson: Advisory Board-Amgen; Consultant-Astellas, Bayer, BMS, Eli-Lilly, Lilly, Merck, Roche/Genentech, Taiho Pharmaceutical
 
Christopher Lieu: Grant/Research Support-Merck
 
Van Morris: Advisory Board, Consultant-Bicara, Incyte; Grant/Research Support-BioNTech, BMS, EMD Serono, Immatics, Pfizer
 
Michael J. Overman: Consultant-AbbVie, Acrotech Biopharma, Agilvax, Janssen Pharmaceuticals, Pfizer, Takeda; Grant/Research Support-Merck
 
Aparna Parikh: Advisory Board-C2I Genomics; Consultant-Checkmate, Eli Lilly, Pfizer; Grant/Research Support-Novartis; Other-Array Biopharma, BMS, Genentech/Roche, Mirati Therapeutics, Plexxicon, Takeda
 
Kanwal PS Raghav: Advisory Board-Daiichi Sankyo; Grant/Research Support-Daiichi Sankyo, Roche/Genentech

Neil H. Segal: Advisory Board-ABL Bio, Boehringer Ingelheim, Roche/Genentech; Grant/Research Support-AstraZeneca, BMS, Immunocore, Merck, Pfizer, Roche/Genentech

Zsofia K. Stadler: Other-Adverum, Allergen, Genentech/Roche, Gyroscope Tx, Neurogene, Novartis, Optos, Regeneron, RegenexBio
 
Josep Tabernero: Consultant-Array Biopharma, AstraZeneca, Bayer, Boehringer Ingelheim, Chugai, Daiichi Sankyo, F. Hoffman-La Roche Ltd., Genentech, HalioDX SAS, Hutchinson MediPharma International, Ikena Oncology, IQVIA, Lilly, Menarini, Merck Serono, Merus, Mirati, MSD, Neophore, Novartis, Orion Biotechnology, Peptomyc, Pfizer, Pierre Fabre, Samsung Bioepis, Sanofi, Seattle Genetics, Servier, Taiho Pharmaceutical, Tessa Therapeutics, TheraMyc
 
The following faculty disclosed no relevant financial relationship with any ineligible company (commercial interest): Mariana Byndloss and Aparna Kalyan

Planning Committee

In addition to the faculty listed above, NACCME and Imedex planners and staff include Samantha Conforti, Kelly Jackson, Mary Johnson, Amanda Mulder, Paul O'Neil, Randy Robbin, Manjusha Sala, and Greaton Sellers.

No NACCME or Imedex planner or staff has disclosed any relevant financial relationship with any ineligible company (commercial interest).

ADA STATEMENT

North American Center for Continuing Medical Education (NACCME) complies with the legal requirements of the Americans with Disabilities Act and the rules and regulations thereof. If any participant in this educational activity is in need of accommodations, please call 609-371-1137.

PRIVACY POLICY

NACCME protects the privacy of personal and other information regarding participants, educational partners, and joint providers. NACCME and our joint providers will not release personally identifiable information to a third party without the individual’s consent, except such information as is required for reporting purposes to the appropriate accrediting agency. NACCME maintains physical, electronic, and procedural safeguards that comply with federal regulations to guard your nonpublic personal information.

Copyright © 2021 by North American Center for Continuing Medical Education, LLC. All rights reserved. No part of this accredited continuing education activity may be reproduced or transmitted in any form or by any means, electronic or mechanical, without first obtaining permission from North American Center for Continuing Medical Education.

GRIEVANCE POLICY

Any participant wanting to file a grievance with respect to any aspect of a continuing education activity accredited by NACCME, LLC may contact Samantha Conforti, Manager, Accreditation and Compliance, by phone at 609-371-1137, by email at sconforti@naccme.com or in writing at 104 Windsor Center Drive, East Windsor, NJ 08520. Ms. Conforti will review the grievance and respond within 30 days of receiving the complaint. If the participant is unsatisfied with the response, an appeal to the Associate Director, Greaton Sellers, Accreditation and Compliance, can be requested for a second level of review. Mr. Sellers can be contacted via email at gsellers@naccme.com.