Systemic Therapy for Hepatocellular Carcinoma Advanced Treatments with Tyrosine Kinase Inhibitors
HCC, which comprises up to 90% of all hepatic malignancies in the United States, is a significant global health burden. The main treatment approach for HCC is surgical resection, but most patients are not eligible due to tumor extent or underlying liver dysfunction. For unresectable intermediate-stage HCC, guideline recommendations advocate the use of loco-regional ablative or transarterial therapies, including embolization (TAE), chemoembolization (TACE), drug-eluting bead-TACE (DEB-TACE), or radioembolization (TARE). There have been a number of advancements in systemic treatment approaches for HCC, including those that utilize protein kinase inhibitors. Sorafenib, lenvatinib, regorafenib, and cabozantinib are TKI options to treat patients with unresectable or advanced HCC. As data continue to emerge with new and emerging agents and various combination strategies, providers who treat patients with HCC will need to integrate them into evidence-based, guideline-directed treatment decisions. How to best sequence these agents and or optimal combinations remains an area of debate requiring collaboration among clinicians and the integration of the most recent, available evidence. As no single treatment will be universally effective due to variations in disease stage and severity, underlying etiology and pathology, and patient characteristics, tailored management plans must be developed that take into account the expertise of the oncology care team, which could include hepatologists, surgeons, interventional radiologists, and community oncologists.
This webcast focuses on the systemic therapy options for HCC with a focus on TKIs.
Provided by North American Center for Continuing Medical Education, LLC (NACCME), an HMP Company.
For questions regarding this educational activity, please call 609-371-1137 or email email@example.com.
This educational activity is designed to meet the educational needs of those who are involved and/or interested in the treatment of patients with GI cancers, community oncologists, physicians, physician assistants, physicians-in-training, oncology nurses, and pharmacists.
After participating in this activity, learners should be better able to:
- Describe the mechanisms, efficacy, safety, and indications of TKIs for the treatment of HCC
- Assess the latest clinical data and rationale surrounding new and emerging TKI-utilizing combination treatment approaches
- Optimize treatment strategies for unresectable HCC across disease stages with evidence-based therapeutic selection, sequences, and management of adverse events (AEs)
To be eligible for credit, participants must complete the online activity and the evaluation. Upon completing the activity, there will be instructions on how to complete the evaluation and print a certificate or other documentation of credit.
Release Date: November 29, 2021
Expiration Date: November 29, 2022
Estimated Time to Complete: 145 minutes
There is no fee associated with this activity.
Supported by educational grants from: Bayer HealthCare Pharmaceuticals, Inc., Exelixis, Inc., and Merck Sharp & Dohme Corp.
In support of improving patient care, this activity has been planned and implemented by North American Center for Continuing Medical Education (NACCME) and Imedex. NACCME is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
NACCME designates this internet enduring activity for a maximum of 2.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
American Academy of Nurse Practitioners National Certification Program accepts AMA PRA Category 1 Credit™ from organizations accredited by the ACCME.
This continuing nursing education internet enduring activity awards 2.75 contact hours.
Provider approved by the California Board of Registered Nursing, Provider #13255 for 2.75 contact hours.
This internet enduring, knowledge-based activity (Universal Activity Number: JA0006201-0000-21-205-H01-P) has been approved for a maximum of 2.75 contact hours (0.275 CEUs).
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USE OF PROPRIETARY NAMES
This continuing medical education activity may include device or medicine brand names for participant clarity purposes only, due to the presence of different branded versions of the same product. No product promotion or recommendation should be inferred.
UNAPPROVED AND/OR INVESTIGATIONAL USES OF DRUGS AND DEVICES
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The faculty has reported the following:
In addition to the faculty listed above, NACCME and Imedex planners and staff include Samantha Conforti, Kelly Jackson, Mary Johnson, Amanda Mulder, Paul O'Neil, Randy Robbin, Manjusha Sala, and Greaton Sellers.
No NACCME or Imedex planner or staff has disclosed any relevant financial relationship with any ineligible company (commercial interest).
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