Post-Test Overcoming Challenges in the Treatment of MDD: Non-Monoaminergic Therapies and Precision Psychiatry Considerations Post-Test Which of the following statements regarding treatment response and remission in MDD is TRUE? Approximately 30% of patients with MDD have TRD Half of patients do not attain remission even after 4 treatment trials Relapse after a year of treatment is uncommon The more treatments to attain remission, the less likely it is that a patient will ultimately relapse Which of the following statements best describes the monoamine hypothesis of depression? Depression is associated with a depletion in acetylcholine, dopamine, and/or serotonin Depression is associated with a depletion in dopamine, norepinephrine, and/or serotonin Depression is associated with a depletion in glutamate, histamine, and/or serotonin Depression is associated with a depletion in GABA, norepinephrine, and/or serotonin Stimulation of which of the following neurotransmitter systems leads to increased neuroplasticity and synaptogenesis, and has been proposed as a mechanism for the rapid therapeutic regulation of excessive default-mode network activity in MDD? Acetylcholine Dopamine Glutamate Serotonin Which of the following treatment options led to rapid antidepressant effects in patients with MDD, including TRD and MDSI, as well as sustained results up to ~4 years in patients with TRD? Aripiprazole Esketamine Olanzapine Quetiapine How confident are you now in your ability to incorporate novel treatment options, such as esketamine, into clinical practice for the management of patients with TRD or MDSI? Very confident Confident Somewhat confident Not very confident Not at all confident Previous
