Pre-Test Surmounting Challenges in the Treatment of MDD: A Light at the End of the Tunnel Pre-Test Based on data from the STAR*D trial of antidepressant sequencing, which of the following statements regarding MDD remission rates based on the HAMD 17 scale is TRUE ? Likelihood of achieving remission is limited and declines with each successive treatment attempt Likelihood of achieving remission is limited but improves with each successive treatment attempt Likelihood of achieving remission is robust and declines with each successive treatment attempt Likelihood of achieving remission is robust and improves with each successive treatment attempt Unsure Stimulation of which of the following neurotransmitter systems leads to increased neuroplasticity and synaptogenesis, and has been proposed as a mechanism for the rapid therapeutic regulation of excessive default-mode network activity in MDD? acetylcholine dopamine glutamate serotonin Unsure Which of the following treatment options for treatment-resistant depression produces rapid and sustained results based on clinical trial data indicating statistically significant improvements in MADRS score at 24 hours and a 51% lower risk of depression relapse (HR 0.49, P=0.003)? dextromethorphan-bupropion esketamine lithium zuranolone Unsure How confident are you in your ability to precisely match effective treatments to subgroups of patients with MDD in a diagnostic category? Very confident Confident Somewhat confident Not very confident Not at all confident
