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New and Emerging ALK/ROS1/NTRK-Targeted Agents in NSCLC: Addressing Treatment Resistance and CNS Metastases


Edward B. Garon, MD, MS
University of California, Los Angeles

Corey J. Langer, MD, FACP
Director of Thoracic Oncology
Abramson Cancer Center, Hospital of the University of Pennsylvania

Jessica J. Lin, MD
Assistant Professor in Medicine
Harvard Medical School

Rajwanth Veluswamy, MD, MSCR
Assistant Professor
Icahn School of Medicine at Mount Sinai


Provided by HMP Education, an HMP Global Company.

For questions regarding this educational activity, or to cancel your account, please call 609-371-1137 or email


This activity is designed me toet the educational needs of medical oncologists, nurses, nurse practitioners, physician assistants, pathologists, pulmonologists, oncology pharmacists, researchers, internists wishing to have an update on the diagnosis and management of lung cancer, and other healthcare professionals interested in the care and treatment of patients with thoracic malignancies.


After participating in this activity, learners should be better able to:

  • Assess guideline recommendations, testing techniques, and clinical applications for molecular profiling to identify patients who will benefit from ALK, ROS1, or NTRK-targeted therapy
  • Evaluate clinical efficacy and safety data for new and emerging ALK, ROS1, and NTRK-targeted agents against treatment resistance and CNS metastases
  • Utilize adverse event management strategies to optimize treatment efficacy and mitigate treatment risks


This on-demand webcast is available with synchronized slides and video/audio.

To be eligible for credit, participants must complete the educational activity, complete the 4-question post-test with a minimum score of 70%, and complete the activity evaluation form. Upon completing the activity, there will be instructions on how to complete the evaluation and print a certificate or other documentation of credit.

Release Date: January 20, 2023.
Expiration Date: January 20, 2024. 
Estimated Time to Complete: 1.00 hour

There is no fee associated with this activity.


The activity is best supported via a computer or device with current versions of the following browsers: Mozilla Firefox, Google Chrome, or Safari. A PDF reader is required for print publications. 


Joint Accreditation with commendation logoIn support of improving patient care, HMP Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Note: This statement is not an indication of approved credits. Please see below for full accreditation details, including credit types and totals, for this activity.


HMP Education designates this internet live/enduring activity for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


This internet live/enduring, knowledge-based activity (Universal Activity Number:  JA0006201-0000-23-026-H01-P) has been approved for a maximum of 1.00 contact hour (.10 CEUs).

The certificate is not the official record of your participation in the activity. The official record of credit will be the information in the CPE Monitor system. Following ACPE Policy, HMP Education must transmit your claim to CPE Monitor within 60 days from the date you complete this CPE activity. HMP Education is not able to report your claimed credit after this 60-day period. Eligibility for pharmacy credit is contingent upon the successful completion of a post-test and/or evaluation for each activity or session attended.


This continuing nursing education internet live/enduring activity awards 1.00 contact hour.

Provider approved by the California Board of Registered Nursing, Provider #13255 for 1.00 contact hour. 


American Academy of Nurse Practitioners National Certification Program accepts AMA PRA Category 1 CreditTM from organizations accredited by the ACCME.


AAPA logoHMP Education has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with the AAPA CME Criteria. This internet enduring activity is designated for 1.00 AAPA Category 1 credit. Approval is valid until January 20, 2024. PAs should only claim credit commensurate with the extent of their participation.


The following Countries, Regions, and Accrediting Bodies accept, or have reciprocity or mutual recognition of credits with the AMA/ACCME. Please contact the accrediting body to find out more information on submitting or converting your credits.

  • Bavarian Chamber of Physicians (Germany)
  • Bulgarian Union of Scientific Medical Societies (Bulgaria)
  • Canadian Medical Association (Canada)
  • Canadian Nurses Association (Canada)
  • EBAC® (European Board for Accreditation of Continuing Education for Health Professionals)
  • Federation of Royal Colleges of Physicians (UK)
  • French National Medical Council (France)
  • Italian Federation of Scientific Medical Societies (Italy)
  • National CME Commission of the Italian Ministry of Health (Italy)
  • Spanish Accreditation Council for CME (Spain)
  • UEMS-EACCME® (European Union of Medical Specialists)


This continuing medical education activity may include device or medicine brand names for participant clarity purposes only, due to the presence of different branded versions of the same product. No product promotion or recommendation should be inferred.


This activity may contain information about experimental and other uses of drugs or devices that are not currently approved by the European Medicines Agency (EMA) of the European Union or the Food and Drug Administration (FDA) of the United States. Participants are strongly encouraged to consult approved product labeling for any drug or device mentioned in this activity before use. The opinions expressed during this activity are the opinions of the respective authors, presenters or moderators and do not necessarily reflect the opinions of HMP Education.


The material presented and related discussions are not intended to be medical advice, and the presentation or discussion of such material is not intended to create and does not establish a provider-patient relationship. Medical advice of any nature should be sought from an individual’s own provider.

The opinions expressed in this educational activity are those of the faculty and are not attributable to HMP Global or any of its subsidiaries or affiliates. Clinical judgment must guide each professional in weighing the benefits of treatment against the risk of toxicity. Dosages, indications, and methods of use for products referred to in this activity are not necessarily the same as indicated in the package insert for each product, may reflect the clinical experience of the presenters, and may be derived from the professional literature or other clinical sources. Consult complete prescribing information before administering.


HMP Education is an independent provider of continuing medical education. HMP Education has no proprietary or financial interest in medical or healthcare products over which the FDA (USA) or EMA (EU) has regulatory authority.

In accordance with our disclosure policies, HMP Education is committed to ensuring balance, independence, objectivity, and scientific rigor for all accredited continuing education. These policies include assigning relevance to, and mitigating, all perceived or real relevant financial relationship (conflicts of interest) between any individual with control over the content and any ineligible company (commercial interest) as defined by the ACCME and CPME.

Any individual with control over accredited content, including planner, faculty, and reviewer, is required to globally disclose:

  1. Individual relationship(s) or lack thereof, and its nature, with any/all ineligible company, and;
  2. Any investigational, off-label, or non-FDA approved content or discussion

HMP Education has reviewed these disclosures, assigned relevance based on the relationship and scope of content, and identified those with the potential to compromise the goals and educational integrity of the education. Relevant relationships, or lack thereof, are shared with the learner.

Education has been independently peer-reviewed to validate content, mitigate identified financial relationships (conflicts of interest), and ensure:

  1. All recommendations involving clinical medicine is based on evidence that is accepted within the medical profession as adequate justification for their indications and contraindications in the care of patients.
  2. All scientific research referred to, reported, or used in accredited continuing education in support or justification of a patient care recommendation conforms to the generally accepted standards of experimental design, data collection, and analysis.
  3. Content is appropriate, fair and balanced, unbiased, referenced, and non-promotional.

All relevant financial relationships have been mitigated.


The faculty has reported the following:

Edward B. Garon: Advisory Board - ABL-Bio, AstraZeneca, Boehringer Ingelheim, Bristol Meyer Squibb, Eisai, Eli Lilly, EMD Serono, Gilead, GSK, Merck, Natera, Novartis, Personalis, Regeneron, Sanofi/Genzyme, Xilio, Zymeworks Biopharm; Grant/Research Support - ABL-Bio, AstraZeneca, Bristol Myer Squibb, Eli Lilly, EMD Serono, Genentech, Iovance, Merck, Mirati, Novartis

Corey J. Langer: Consultant - AstraZeneca; Grant/Research Support - Pfizer, Lilly, Advantagene, Inovio, Celgene, Vertex, Ariad (Takeda), Merck, Stemcentrex, Genentech/Roche, AstraZeneca, Trizell, GSK, Guardant; Other Material Support(Data Safety Monitoring) - Lilly, Amgen, Peregrine, Incyte, SWOG, Oncocyte; Advisory Board - Bristol Myers Squibb, Lilly, Pfizer, Synta, Boehringer-Ingelheim, AstraZeneca, Novartis, Abbott, Genentech/Roche, Savient, Bayer/Onyx, Celgene, Clarient, Clovis, Guardant, Merck, Gilead

Jessica J. Lin: Consultant - 14ner/Elevation Oncology, Bayer, Blueprint Medicines Corporation, C4 Therapeutics, Mirati Therapeutics, Novartis, Nuvalent, Pfizer, Turning Point Therapeutics; Grant/Research Support - 14ner/Elevation Oncology, Bayer, Genentech/Roche, Hengrui Therapeutics, Linnaeus Therapeutics, Loxo Oncology, Neon Therapeutics, Novartis, Nuvalent, Pfizer, Relay Therapeutics, Turning Point Therapeutics; Advisory Board - Genentech/Roche; Institutional Research Funding - 14ner/Elevation Oncology, Bayer, Linnaeus Therapeutics, Novartis, Nuvalent, Pfizer, Relay Therapeutics, Turning Point Therapeutics

Rajwanth Veluswamy: Advisory Board - AstraZeneca, BergenBio, Regeneron; Consultant - BeiGene; Grant/Research Support - AstraZeneca, Boerhinger Ingelheim, Bristol Myers Squibb, OncoNova; Speakers Bureau - AstraZeneca



HMP Education planners and staff include Kelly Jackson; Samantha Joy; Kayli McGovern; Randy Robbin; and Andrea Zimmerman, EdD.

No HMP Education planner or staff has disclosed a relevant financial relationship with any ineligible company (commercial interest).


HMP Education complies with the legal requirements of the Americans with Disabilities Act and the rules and regulations thereof. If any participant in this educational activity needs accommodations, please call 609-371-1137.


HMP Education protects the privacy of personal and other information regarding participants, educational partners, and joint providers. HMP Education and our joint providers will not release personally identifiable information to a third party without the individual’s consent, except such information as is required for reporting purposes to the appropriate accrediting agency. HMP Education maintains physical, electronic, and procedural safeguards that comply with federal regulations to guard your nonpublic personal information.

Copyright © 2023 by HMP Education. All rights reserved. No part of this accredited continuing education activity may be reproduced or transmitted in any form or by any means, electronic or mechanical, without first obtaining permission from HMP Education.


Any participant wanting to file a grievance with respect to any aspect of a continuing education activity accredited by HMP Education may contact Samantha Joy, Senior Manager, Accreditation and Compliance, by phone at 609-371-1137, by email at or in writing at 104 Windsor Center Drive, East Windsor, NJ 08520. Ms. Joy will review the grievance and respond within 30 days of receiving the complaint.


Supported by an independent educational grant from Turning Point Therapeutics.