This course closed on Tuesday, August 22, 2023

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Bruton’s Tyrosine Kinase Inhibitors in the Treatment of CLL/SLL: The Next Generation


Farrukh Awan, MD
Associate Professor of Internal Medicine, Director of Lymphoid Malignancies Program
UT Southwestern Medical Center

Matthew S. Davids, MD MMSc
Director of Clinical Research, Division of Lymphoma / Associate Professor of Medicine
Dana-Farber Cancer Institute / Harvard Medical School

Nitin Jain, MD
Associate Professor
The University of Texas MD Anderson Cancer Center

John P. Leonard, MD
Senior Associate Dean for Innovation and Initiatives; Executive Vice Chair, Weill Department of Medicine; Richard T. Silver Distinguished Professor of Hematology and Medical Oncology
Weill Cornell Medicine/New York Presbyterian

Peter Martin, MD
Associate Professor of Medicine
Weill Cornell Medicine/New York Presbyterian


Provided by HMP Education, an HMP Global Company.

For questions regarding this educational activity, or to cancel your account, please call 609-371-1137 or email


This activity is designed to meet the educational needs of U.S. hematologists, medical oncologists, and other health-care professionals (physicians, physicians-in-training, oncology nurses, pharmacists, physician assistants, etc) who are involved and/or interested in the treatment of patients with multiple myeloma, lymphoma, chronic lymphocytic leukemia, acute myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms.


After participating in this activity, learners should be better able to:

  • Compare the efficacy and safety data for current and emerging BTK inhibitors for the treatment of CLL/SLL
  • Evaluate long-term patient outcomes data for BTK inhibitors in the treatment of CLL/SLL
  • Anticipate and manage adverse events when treating patients with CLL/SLL with BTK inhibitors and with combined targeted therapy


This on-demand webcast is available with synchronized slides and audio.

To be eligible for credit, participants must complete the educational activity, complete the X-question post-test with a score of 70% or better, and complete the evaluation form. Upon completing the activity, there will be instructions on how to complete the evaluation and print a certificate or other documentation of credit.

Release Date: August 23, 2022 
Expiration Date: August 22, 2023
Estimated Time to Complete: 1.75 hour

There is no fee associated with this activity.


The evaluation is accessible after the activity via a PC or Mac computer with current versions of the following browsers: Mozilla Firefox, Google Chrome, or Safari. A PDF reader is required for print publications. 


In support of improving patient care, HMP Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


HMP Education designates this internet enduring activity for a maximum of 1.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


This internet enduring, knowledge-based activity (Universal Activity Number: JA0006201-0000-22-142-H01-P) has been approved for a maximum of 1.75 contact hour (.18 CEUs).

The certificate is not the official record of your participation in the activity. The official record of credit will be the information in the CPE Monitor system. Following ACPE Policy, HMP Education must transmit your claim to CPE Monitor within 60 days from the date you complete this CPE activity. HMP Education is not able to report your claimed credit after this 60-day period. Eligibility for pharmacy credit is contingent upon the successful completion of a post-test and/or evaluation for each activity or session attended.


This continuing nursing education internet enduring activity awards 1.75 contact hour.

Provider approved by the California Board of Registered Nursing, Provider #13255 for 1.75 contact hour. 


American Academy of Nurse Practitioners National Certification Program accepts AMA PRA Category 1 CreditTM from organizations accredited by the ACCME.


HMP Education has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with the AAPA CME Criteria. This internet enduring activity is designated for 1.75 AAPA Category 1 credit(s). PAs should only claim credit commensurate with the extent of their participation.



This continuing medical education activity may include device or medicine brand names for participant clarity purposes only, due to the presence of different branded versions of the same product. No product promotion or recommendation should be inferred.


This activity may contain information about experimental and other uses of drugs or devices that are not currently approved by the European Medicines Agency (EMA) of the European Union or the Food and Drug Administration (FDA) of the United States. Participants are strongly encouraged to consult approved product labeling for any drug or device mentioned in this activity before use. The opinions expressed during this activity are the opinions of the respective authors, presenters or moderators and do not necessarily reflect the opinions of HMP Education.


The material presented and related discussions are not intended to be medical advice, and the presentation or discussion of such material is not intended to create and does not establish a physician-patient relationship. Medical advice of any nature should be sought from an individual’s own physician.

Neither HMP Education nor any of its subsidiaries or affiliates is affiliated with, or formally endorsed by a medical society.

The opinions expressed in this educational activity are those of the faculty and are not attributable to HMP Education or HMP. Clinical judgment must guide each professional in weighing the benefits of treatment against the risk of toxicity. Dosages, indications, and methods of use for products referred to in this activity are not necessarily the same as indicated in the package insert for each product, may reflect the clinical experience of the presenters, and may be derived from the professional literature or other clinical sources. Consult complete prescribing information before administering.


HMP Education is an independent provider of continuing medical education. HMP Education has no proprietary or financial interest in medical or healthcare products over which the FDA (USA) or EMA (EU) has regulatory authority.

In accordance with our disclosure policies, HMP Education is committed to ensuring balance, independence, objectivity, and scientific rigor for all accredited continuing education. These policies include assigning relevance to, and mitigating, all perceived or real conflicts of interest between any individual with control over the content and any ineligible company (commercial interest) as defined by the ACCME.

Any individual with control over accredited content, including planner, faculty, and reviewer, is required to globally disclose:

  1. Individual relationship(s) or lack thereof, and its nature, with any/all ineligible company, and;
  2. Any investigational, off-label, or non-FDA approved content or discussion

HMP Education has reviewed these disclosures, assigned relevance based on the relationship and scope of content, and identified those with the potential to compromise the goals and educational integrity of the education. Relevant relationships, or lack thereof, are shared with the learner.

Education has been independently peer-reviewed to validate content, mitigate identified conflicts of interest, and ensure:

  1. All recommendations involving clinical medicine is based on evidence that is accepted within the medical profession as adequate justification for their indications and contraindications in the care of patients.
  2. All scientific research referred to, reported, or used in accredited continuing education in support or justification of a patient care recommendation conforms to the generally accepted standards of experimental design, data collection, and analysis.
  3. Content is appropriate, fair and balanced, unbiased, referenced, and non-promotional.


The faculty has reported the following:

Farrukh Awan, MD: Consultant - Abbvie; Consultant - ADCT Therapeutics; Consultant - BeiGene; Consultant - Bristol Myers Squibb; Consultant - Cardinal Health; Consultant - Celgene; Consultant - DAVA Oncology; Advisory Board - Epizyme; Consultant - Genentech; Consultant - Gilead Sciences; Consultant - Incyte; Consultant - Janssen; Consultant - Johnson and Johnson; Consultant - Karyopharm; Consultant - Kite Pharma, Inc.; Consultant - MEI Pharma; Consultant - Merck; Consultant - Pharmacyclics; Consultant - Verastem

Matthew Davids, MD, MMSc: Advisory Board, Consultant - AbbVIe; Advisory Board, Consultant - Adaptive Biotechnologies; Grant/Research Support - Ascentage Pharma; Advisory Board, Consultant, Grant/Research Support - AstraZeneca; Advisory Board, Consultant - BeiGene; Advisory Board, Consultant - Bristol Myers Squibb; Advisory Board, Consultant - Eli Lilly; Advisory Board, Consultant, Grant/Research Support - Genentech; Advisory Board, Consultant - Janssen; Grant/Research Support - MEI Pharma; Advisory Board, Consultant - Merck; Grant/Research Support - Novartis; Consultant - Ono Pharmaceuticals; Advisory Board, Consultant, Grant/Research Support - Pharmacyclics; Consultant - Research to Practice; Grant/Research Support - Surface Oncology; Advisory Board, Consultant, Takeda; Advisory Board, Consultant - TG Therapeutics; Consultant, Grant/Research Support - Verastem

Nitin Jain: Consultant, Grant/Research Support, Speakers Bureau - AbbVie; Consultant, Grant/Research Support, Speakers Bureau - Adaptive Biotechnologies; Consultant, Grant/Research Support, Speakers Bureau - ADCT Therapeutics; Grant/Research Support - Aprea; Consultant, Grant/Research Support, Speakers Bureau - AstraZeneca; Consultant, Speakers Bureau - BeiGene; Grant/Research Support - Bristol Myers Squibb; Grant/Research Support - Cellectis; Grant/Research Support - Fate Therapeutics; Consultant, Grant/Research Support, Speakers Bureau - Genentech; Grant/Research Support - Incyte; Advisory Board, Consultant, Speakers Bureau - Janssen; Grant/Research Support - Pfizer; Consultant, Grant/Research Support, Speakers Bureau - Pharmacyclics; Consultant, Grant/Research Support, Speakers Bureau - Precision Biosciences; Consultant, Grant/Research Support, Speakers Bureau - Servier; Consultant, Speakers Bureau - TG Therapeutics

John P. Leonard: Consultant - AbbVie, Bayer, Bristol Myers Squibb/Celgene, Eisai, Epizyme, GenMab, Genentech/Roche, Gilead/Kite, Incyte, Janssen, Mustang Bio, Second Genome, Sutro

Peter Martin: Consultant - BeiGene; Consultant - Epizyme; Consultant - Gilead; Consultant - Janssen; Consultant - Takeda



Susie Seaman, NP, MSN, CWCN, CWS (nurse planner)
Wound Clinic, Family Health Centers of San Diego
San Diego, California

Ms. Seaman has disclosed no relevant financial relationship with any ineligible company (commercial interest).

HMP Education planners and staff include Samantha Conforti, Kelly Jackson, Amrita Kabi, Randy Robbin, and Andrea Zimmerman.

No HMP Education planner or staff has disclosed a relevant financial relationship with any ineligible company (commercial interest).


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Supported by an independent educational grant from Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC,.